Neuroleptic malignant syndrome (NMS) which can cause death. Let you know healthcare service provider immediately When you have any of the following signs and symptoms of NMS: high fever
Promethazine Hydrochloride and Codeine Phosphate Oral Solution is usually a prescription medicine used in Grownups to temporarily treat cough and upper respiratory signs and symptoms that you could have with allergies or a common cold.
g., Those people with proof of improved intracranial pressure or Mind tumors), promethazine HCl and codeine phosphate oral Answer could minimize respiratory drive, as well as resultant CO2 retention can additional maximize intracranial stress. Furthermore, opioids generate adverse reactions which will obscure the scientific class of individuals with head accidents.
Before you get Promethazine with Codeine Oral Option, explain to your healthcare supplier about all your clinical ailments, which includes in the event you: have a drug dependence
Evaluate Each and every client’s hazard ahead of prescribing promethazine HCl and codeine phosphate oral Option, prescribe promethazine HCl and codeine phosphate oral Alternative for the shortest length that's in line with personal individual remedy aims, monitor all people on a regular basis for the development of addition or abuse, and refill only immediately after reevaluation of the need for ongoing treatment. [see Warnings and Safety measures (5.1)]
Hemodialysis is just not routinely used to boost the elimination of codeine or promethazine from your body.
Even though the possibility of dependancy in almost any personal is unidentified, it might take place in individuals properly prescribed promethazine HCl and codeine phosphate oral Option. Addiction can occur at proposed dosages and In case the drug is misused or abused. Pitfalls are elevated in people with a personal or family historical past of substance abuse (which include drug or alcohol abuse or habit) or psychological sickness (e.g., important depression).
Fetal/Neonatal Adverse Reactions Extended use of opioid analgesics all through pregnancy for clinical or nonmedical needs may end up in Actual physical dependence from the neonate and neonatal opioid withdrawal syndrome Soon following delivery.
MAOI Conversation Tell sufferers never to acquire promethazine HCl and codeine phosphate oral Option whilst making use of or in fourteen days of stopping any drugs that inhibit monoamine oxidase.
Stimulation may very well be evident, particularly in kids and geriatric clients. Convulsions may possibly rarely come about. A paradoxical reaction has actually been reported in little ones receiving solitary doses get more info of seventy five mg to a hundred twenty five mg orally, characterised by hyperexcitability and nightmares.
Promethazine HCl and codeine phosphate oral Answer will not be suggested for use in pregnant women. Prolonged use of promethazine HCl and codeine phosphate oral Option throughout pregnancy may lead to neonatal opioid withdrawal syndrome, which can be lifestyle-threatening if not identified and addressed.
There aren't any offered info with promethazine HCl and codeine phosphate oral Option use in Expecting Ladies to inform a drug-connected hazard for adverse developmental results.
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e., several copies of your gene for cytochrome P450 isoenzyme 2D6 or higher morphine concentrations). Little ones with slumber apnea might be notably sensitive on the respiratory depressant outcomes of codeine.